Difference between revisions of "NadC"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27860 nadC]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27860 nadC]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=NadC NadC]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 5.18   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 5.18   

Revision as of 11:48, 8 April 2014

  • Description: nicotinate-nucleotide diphosphorylase (carboxylating)

Gene name nadC
Synonyms yrxB
Essential no
Product nicotinate-nucleotide diphosphorylase (carboxylating)
Function NAD biosynthesis
Gene expression levels in SubtiExpress: nadC
Metabolic function and regulation of this protein in SubtiPathways:
NadC
MW, pI 31 kDa, 5.18
Gene length, protein length 867 bp, 289 aa
Immediate neighbours nadA, nadB
Sequences Protein DNA DNA_with_flanks
Genetic context
NadC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
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Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

  • Locus tag: BSU27860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: nadC/modD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References