nadA

nadA
168

quinolinate synthetase

locus
BSU_27850
Molecular weight
41.33 kDa
pI
5.72
Protein length
Gene length
function
NAD biosynthesis
product
quinolinate synthetase
essential
no
ec
2.5.1.72
synonyms
nadA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0379 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,845,955 → 2,847,061
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The protein
Catalyzed reaction/ biological activity
ATP + L-threonyl-[protein] --> ADP + H+ + O-phospho-L-threonyl-[protein] (according to UniProt)
Protein family
quinolinate synthase A family (single member, according to UniProt)
[wiki|Cofactors]
Fe-S cluster [Pubmed|18959769]
Structure
[PDB|4HHE] (from Pyrococcus furiosus, 34% identity) [pubmed|23999292]
[AF|Q9KWZ1]
Expression and Regulation
Operons
genes
[gene|D30D059185DFB828AB0FD07D600DBC3FD0973198|nadB]-[gene|1368734DCC28C618AA173B865784BDDAEA912623|nadC]-[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]
description
[Pubmed|8444804]
regulation
repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]
regulatory mechanism
[protein|510DE075EA964D22C42DEB171509F6CDA600A402|nadR]: repression, [Pubmed|16199587], in [regulon|protein:510DE075EA964D22C42DEB171509F6CDA600A402|nadR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8444804], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
An [wiki|search|ncRNA] is predicted for '[protein|search|nadB]' [PubMed|20525796]
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[gene|D30D059185DFB828AB0FD07D600DBC3FD0973198|nadB]→[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]

2024-03-23 20:37:09

ghost

78

4f70dedfb39fe2edf4df8c48406b789cb6f009f0

0DADAB25BF759B1341F8AD45873BE220231A782F

Biological materials
Mutant
BKE27850 (Δ[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27850 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCATTCGATTGTTTGA,  downstream forward: _UP4_TAGATCAGAAATATTTTCCC
BKK27850 (Δ[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27850 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCATTCGATTGTTTGA,  downstream forward: _UP4_TAGATCAGAAATATTTTCCC
labs
[wiki|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]
References
18959769,16199587,8444804,23999292

F92F17578F06EF2292D0923662933463D7C86498

Page visits: 2675

Time of last update: 2024-03-28 20:00:32

Author of last update: Melvin.boenninger