MurC

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  • Description: UDP-N-acetylmuramoyl-L-alanine synthetase

Gene name murC
Synonyms ytxF
Essential yes PubMed
Product UDP-N-acetylmuramoyl-L-alanine synthetase
Function peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: murC
Metabolic function and regulation of this protein in SubtiPathways:
Cell wall
MW, pI 48 kDa, 5.307
Gene length, protein length 1296 bp, 432 aa
Immediate neighbours ytxG, sftA
Sequences Protein DNA DNA_with_flanks
Genetic context
MurC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MurC expression.png




























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29790

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine (according to Swiss-Prot)
  • Protein family: murCDEF family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720] [WorldCat.org] [DOI] (P p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

D Varón, M S Brody, C W Price
Bacillus subtilis operon under the dual control of the general stress transcription factor sigma B and the sporulation transcription factor sigma H.
Mol Microbiol: 1996, 20(2);339-50
[PubMed:8733232] [WorldCat.org] [DOI] (P p)