mtnW

mtnW
168

2,3-diketo-5-methylthiopentyl-1-phosphate enolase, Rubisco-like protein

locus
BSU_13590
Molecular weight
44.89 kDa
pI
5.28
Protein length
Gene length
function
methionine salvage
product
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
essential
no
ec
null
synonyms
mtnW, ykrW

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1850 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,427,034  1,428,278
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The protein
Catalyzed reaction/ biological activity
5-methylsulfanyl-2,3-dioxopentyl phosphate --> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate (according to UniProt)
Protein family
RuBisCO large chain family (single member, according to UniProt)
Structure
[PDB|2ZVI] [Pubmed|19690372]
[AF|O31666]
Expression and Regulation
Operons
genes
[gene|42D2F9B958F62DFE447A1321E4109D676ECB899C|mtnW]-[gene|91633E6AF9A715166AE05BD7E540463DE352AA20|mtnX]-[gene|337F1E27C2E380DF8DCADE3581F74CFF52AFD224|mtnB]-[gene|C7D9E701B2CA2C9E85D69CAD6E0A45BE590BAED9|mtnD]
description
[Pubmed|12022921]
regulation
induced by methionine starvation ([wiki|S-box]) [Pubmed|10094622]
regulatory mechanism
S-box: RNA switch, , the [wiki|S-box] [wiki|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622], in [regulon|other_regulator:S-box|S-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12022921], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|42D2F9B958F62DFE447A1321E4109D676ECB899C|mtnW]→[gene|C7D9E701B2CA2C9E85D69CAD6E0A45BE590BAED9|mtnD]

2024-02-10 23:58:57

Jstuelk

44

a2b13ba83890892f9d8595d5e452be227045e93c

6416B0A5CDDC144986D3159AFC5B04D4507F2AE1

Biological materials
Mutant
BKE13590 ([gene|42D2F9B958F62DFE447A1321E4109D676ECB899C|mtnW]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13590 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCCAGAGCTCCTTTCAT,  downstream forward: _UP4_AAATGGGGAAAGGCTGAAGC
BKK13590 ([gene|42D2F9B958F62DFE447A1321E4109D676ECB899C|mtnW]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13590 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCCAGAGCTCCTTTCAT,  downstream forward: _UP4_AAATGGGGAAAGGCTGAAGC
References
10094622,19279009,12022921,14551435,11914366,12107147,19194007,15102328,19690372,12787499,18039762

42D2F9B958F62DFE447A1321E4109D676ECB899C

Page visits: 3758

Time of last update: 2024-03-28 08:53:57

Author of last update: Melvin.boenninger