MtlD

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  • Description: mannitol-1-phosphate 5-dehydrogenase

Gene name mtlD
Synonyms mtlB
Essential no
Product mannitol-1-phosphate 5-dehydrogenase
Function mannitol utilization
Gene expression levels in SubtiExpress: mtlD
Metabolic function and regulation of this protein in SubtiPathways:
mtlD
MW, pI 40 kDa, 6.291
Gene length, protein length 1098 bp, 366 aa
Immediate neighbours mtlF, ycsA
Sequences Protein DNA DNA_with_flanks
Genetic context
MtlD context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

MtlR regulon

The gene

Basic information

  • Locus tag: BSU03990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH (according to Swiss-Prot)
  • Protein family: mannitol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3H2Z (from Shigella flexneri 2a str. 2457t mutant, 42% identity, 59% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References