Difference between revisions of "MscL"

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(Reviews)
(Extended information on the protein)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
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* '''[[SubtInteract|Interactions]]:'''
  
* '''Localization:''' cell membrane [http://www.ncbi.nlm.nih.gov/sites/entrez/19252899 PubMed]
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* '''[[Localization]]:''' cell membrane [http://www.ncbi.nlm.nih.gov/sites/entrez/19252899 PubMed]
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 18:09, 2 December 2011

  • Description: large conductance mechanosensitive channel protein, prevents selective release of cytoplasmic proteins in a hypotonic environment

Gene name mscL
Synonyms ywpC
Essential no
Product large conductance mechanosensitive channel protein
Function resistance to osmotic downshockglycine betaine export
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 14 kDa, 4.649
Gene length, protein length 390 bp, 130 aa
Immediate neighbours ywpD, ywpB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MscL context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

coping with hypo-osmotic stress, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU36360

Phenotypes of a mutant

sensitive to osmotic downshock (> 0.5 M) during logarithmic growth PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: mscL family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3HZQ (MscL of Staphylococcus aureus) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed in logarithmic phase PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Erhard Bremer, University of Marburg, Germany homepage

Your additional remarks

References

Reviews


Original Publications