MntH

• Description: manganese transporter (proton symport)
  
  

Gene name	mntH
Synonyms	ydaR
Essential	no
Product	manganese transporter (proton symport))
Function	manganese uptake
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	45 kDa, 9.889
Gene length, protein length	1275 bp, 425 aa
Immediate neighbours	ydzK, ydaS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

MntR regulon

The gene

Basic information

• Locus tag: BSU04360

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: NRAMP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96593

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntH PubMed

• Sigma factor:

• Regulation: repressed by Mn(2+) (MntR) PubMed
  • repressed at high Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism: MntR: transcription repression PubMed
  • MntR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

Emmanuel Guedon, Charles M Moore, Qiang Que, Tao Wang, Rick W Ye, John D Helmann
The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.
Mol Microbiol: 2003, 49(6);1477-91
[PubMed:12950915] [WorldCat.org] [DOI] (P p)

Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146] [WorldCat.org] [DOI] (P p)