Difference between revisions of "MntB"

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* '''Regulation:''' repressed by Mn(2+) ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 
* '''Regulation:''' repressed by Mn(2+) ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 +
** activated at low Mn(II) concentrations (MntR) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
  
 
* '''Regulatory mechanism:''' MntR: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 
* '''Regulatory mechanism:''' MntR: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 +
** [[MntR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  

Revision as of 16:55, 11 June 2009

  • Description: manganese ABC transporter (ATP-binding protein)

Gene name mntB
Synonyms ytgB
Essential no
Product manganese ABC transporter (ATP-binding protein)))
Function manganese uptake
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 27 kDa, 9.411
Gene length, protein length 750 bp, 250 aa
Immediate neighbours mntC, mntA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MntB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU30760

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ABC transporter family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: repressed by Mn(2+) (MntR) PubMed
    • activated at low Mn(II) concentrations (MntR) PubMed
  • Regulatory mechanism: MntR: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146] [WorldCat.org] [DOI] (P p)

  1. Que Q, Helmann JD. (2000) Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins. Mol Microbiol. Mar;35(6): 1454-68. PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed