Difference between revisions of "MnaA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU35660 mnaA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35660 mnaA]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.469   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.469   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tagU]]'', ''[[gtaB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tagU]]'', ''[[gtaB]]''
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15583&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35660 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35660 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35660 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yvyH_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yvyH_context.gif]]

Revision as of 14:00, 13 May 2013

  • Description: UDP-N-acetylglucosamine 2-epimerase

Gene name mnaA
Synonyms yvyH
Essential yes PubMed
Product UDP-N-acetylglucosamine 2-epimerase
Function biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: mnaA
MW, pI 42 kDa, 5.469
Gene length, protein length 1140 bp, 380 aa
Immediate neighbours tagU, gtaB
Sequences Protein DNA Advanced_DNA
Genetic context
YvyH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MnaA expression.png
























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU35660

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine (according to Swiss-Prot)
  • Protein family: UDP-N-acetylglucosamine 2-epimerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Blazenka Soldo, Vladimir Lazarevic, Harold M Pooley, Dimitri Karamata
Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase.
J Bacteriol: 2002, 184(15);4316-20
[PubMed:12107153] [WorldCat.org] [DOI] (P p)