Difference between revisions of "MgsR"

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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html]
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770]
  
 
* '''Structure:'''
 
* '''Structure:'''

Latest revision as of 14:13, 2 April 2014

  • Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress

Gene name mgsR
Synonyms yqgZ
Essential no
Product transcriptional regulator
Function controls a subset of general stress genes
Gene expression levels in SubtiExpress: mgsR
Interactions involving this protein in SubtInteract: MgsR
MW, pI 14 kDa, 9.28
Gene length, protein length 378 bp, 126 aa
Immediate neighbours trnSL-Gln1, yqgY
Sequences Protein DNA DNA_with_flanks
Genetic context
YqgZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MgsR expression.png

















Categories containing this gene/protein

transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigB regulon, MgsR regulon

The gene

Basic information

  • Locus tag: BSU24770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
  • Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
  • Paralogous protein(s): Spx

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • MgsR: transcription activation PubMed
  • Additional information:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
    • MgsR is subject to rapid proteolytic degradation by ClpX-ClpP and ClpC-ClpP PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Alexander Reder, Dierk-Christoph Pöther, Ulf Gerth, Michael Hecker
The modulator of the general stress response, MgsR, of Bacillus subtilis is subject to multiple and complex control mechanisms.
Environ Microbiol: 2012, 14(10);2838-50
[PubMed:22812682] [WorldCat.org] [DOI] (I p)

Alexander Reder, Dirk Höper, Ulf Gerth, Michael Hecker
Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3601-10
[PubMed:22582280] [WorldCat.org] [DOI] (I p)

Alexander Reder, Dirk Höper, Christin Weinberg, Ulf Gerth, Martin Fraunholz, Michael Hecker
The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis.
Mol Microbiol: 2008, 69(5);1104-20
[PubMed:18643936] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)