Difference between revisions of "MgsR"

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= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[SigB regulon]]}}
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{{SubtiWiki regulon|[[SigB regulon]]}},
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{{SubtiWiki regulon|[[MgsR regulon]]}}
  
 
=The gene=
 
=The gene=
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Modification:'''
 
* '''Modification:'''
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** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}}
  
 
* '''Cofactor(s):'''
 
* '''Cofactor(s):'''
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* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
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** MgsR: transcription activation {{PubMed|22812682}}
 
* '''Additional information:'''
 
* '''Additional information:'''
 +
** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}}
 +
** [[MgsR]] is subject to rapid proteolytic degradation by [[ClpX]]-[[ClpP]] and [[ClpC]]-[[ClpP]] {{PubMed|22812682}}
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
  
<pubmed>18643936,,12107147 15805528 18643936, </pubmed>
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<pubmed>18643936, 22812682,12107147 15805528 18643936, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:30, 23 July 2012

  • Description: transcriptional regulator of a subset of the SigB general stress regulon

Gene name mgsR
Synonyms yqgZ
Essential no
Product transcriptional regulator
Function controls a subset of general stress genes
Interactions involving this protein in SubtInteract: MgsR
MW, pI 14 kDa, 9.28
Gene length, protein length 378 bp, 126 aa
Immediate neighbours trnSL-Gln1, yqgY
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YqgZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MgsR expression.png

















Categories containing this gene/protein

transcription factors and their control, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon, MgsR regulon

The gene

Basic information

  • Locus tag: BSU24770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
  • Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
  • Paralogous protein(s): Spx

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • MgsR: transcription activation PubMed
  • Additional information:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
    • MgsR is subject to rapid proteolytic degradation by ClpX-ClpP and ClpC-ClpP PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References