Difference between revisions of "Metabolism of signalling nucleotides"

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* [[GdpP]]
 
* [[GdpP]]
  
===c-di-GMP degradation===
+
===c-di-GMP degradation (presence of an EAL domain)===
 +
* [[YkoW]]
 
* [[YkuI]]
 
* [[YkuI]]
 +
* [[YuxH]]
  
===c-di-GMP synthesis and degradation/ based on similarity===
+
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)===
 +
* [[GdpP]]
 +
* [[YdaK]]
 
* [[YhcK]]
 
* [[YhcK]]
 
* [[YkoW]]
 
* [[YkoW]]
 
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues)
 
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues)
 +
 +
=== Targets of signalling nucleotides ===
 +
* ppGpp targets
 +
** GdpP
 +
 +
* c-di-GMP targets
 +
** YpfA (contains a PilZ domain)
  
 
==Important original publications==
 
==Important original publications==

Revision as of 11:59, 24 July 2012

Parent categories
Neighbouring categories
Related categories

none

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

c-di-AMP degradation

c-di-GMP degradation (presence of an EAL domain)

c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)

Targets of signalling nucleotides

  • ppGpp targets
    • GdpP
  • c-di-GMP targets
    • YpfA (contains a PilZ domain)

Important original publications

Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650] [WorldCat.org] [DOI] (I p)

Important reviews

Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104] [WorldCat.org] [DOI] (I p)

Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011] [WorldCat.org] [DOI] (I p)

Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449] [WorldCat.org] [DOI] (I p)

Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086] [WorldCat.org] [DOI] (I e)

Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514] [WorldCat.org] [DOI] (P p)

Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609] [WorldCat.org] [DOI] (P p)

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