Difference between revisions of "Metabolism of signalling nucleotides"

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(Important original publications)
(Targets of signalling nucleotides)
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** [[YkuI]]
 
** [[YkuI]]
  
* potential c-di-AMP targets
+
* c-di-AMP targets
 
** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}
 
** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}
 +
** the [[ydaO riboswitch]] {{PubMed|24141192}}
  
 
==Important original publications==
 
==Important original publications==

Revision as of 17:03, 14 December 2013

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

c-di-GMP degradation (presence of an EAL domain)

c-di-GMP synthesis

Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • other c-di-GMP-binding proteins

Important original publications

James W Nelson, Narasimhan Sudarsan, Kazuhiro Furukawa, Zasha Weinberg, Joy X Wang, Ronald R Breaker
Riboswitches in eubacteria sense the second messenger c-di-AMP.
Nat Chem Biol: 2013, 9(12);834-9
[PubMed:24141192] [WorldCat.org] [DOI] (I p)

Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116] [WorldCat.org] [DOI] (I p)

Felix M P Mehne, Katrin Gunka, Hinnerk Eilers, Christina Herzberg, Volkhard Kaever, Jörg Stülke
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.
J Biol Chem: 2013, 288(3);2004-17
[PubMed:23192352] [WorldCat.org] [DOI] (I p)

Allison Kriel, Alycia N Bittner, Sok Ho Kim, Kuanqing Liu, Ashley K Tehranchi, Winnie Y Zou, Samantha Rendon, Rui Chen, Benjamin P Tu, Jue D Wang
Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.
Mol Cell: 2012, 48(2);231-41
[PubMed:22981860] [WorldCat.org] [DOI] (I p)

Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650] [WorldCat.org] [DOI] (I p)


Important reviews


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