Difference between revisions of "Metabolism of signalling nucleotides"
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===c-di-GMP degradation (presence of an EAL domain)=== | ===c-di-GMP degradation (presence of an EAL domain)=== | ||
| − | * [[ | + | * [[DgcW]] |
* [[YkuI]] | * [[YkuI]] | ||
| − | * [[ | + | * [[PdeH]] |
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)=== | === c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)=== | ||
* [[GdpP]] | * [[GdpP]] | ||
* [[YdaK]] | * [[YdaK]] | ||
| − | * [[ | + | * [[DgcK]] |
| − | * [[ | + | * [[DgcW]] |
| − | * [[ | + | * [[DgcP]] (this enzyme lacks important residues) |
=== Targets of signalling nucleotides === | === Targets of signalling nucleotides === | ||
| Line 52: | Line 52: | ||
* c-di-GMP targets | * c-di-GMP targets | ||
| − | ** [[ | + | ** [[DgrA]] (contains a PilZ domain) |
* potential c-di-AMP targets | * potential c-di-AMP targets | ||
| − | ** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}} | + | ** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}} |
==Important original publications== | ==Important original publications== | ||
Revision as of 10:33, 10 August 2013
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| Related categories |
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Contents
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
c-di-GMP degradation (presence of an EAL domain)
c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)
Targets of signalling nucleotides
- c-di-GMP targets
- DgrA (contains a PilZ domain)
Important original publications
Important reviews
Rebecca M Corrigan, Angelika Gründling
Cyclic di-AMP: another second messenger enters the fray.
Nat Rev Microbiol: 2013, 11(8);513-24
[PubMed:23812326]
[WorldCat.org]
[DOI]
(I p)
Dimpy Kalia, Gökçe Merey, Shizuka Nakayama, Yue Zheng, Jie Zhou, Yiling Luo, Min Guo, Benjamin T Roembke, Herman O Sintim
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.
Chem Soc Rev: 2013, 42(1);305-41
[PubMed:23023210]
[WorldCat.org]
[DOI]
(I p)
Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104]
[WorldCat.org]
[DOI]
(I p)
Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011]
[WorldCat.org]
[DOI]
(I p)
Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449]
[WorldCat.org]
[DOI]
(I p)
Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086]
[WorldCat.org]
[DOI]
(I e)
Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514]
[WorldCat.org]
[DOI]
(P p)
Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609]
[WorldCat.org]
[DOI]
(P p)
