metS

168

methionyl-tRNA synthetase

locus: BSU_00380

Molecular weight: 76.01 kDa

pI: 4.96

Protein length: 664 aa

Gene length: 1995 bp

function: translation

product: methionyl-tRNA synthetase

essential: yes

ec: 6.1.1.10

synonyms: metS, metG

List of homologs in different organisms, belongs to COG0143 (Galperin et al., 2021)

Gene

Coordinates: 45,633 → 47,627

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Catalyzed reaction/ biological activity

• ATP + L-methionine + tRNA^Met --> AMP + diphosphate + L-methionyl-tRNA^Met (according to UniProt)

Protein family

• [wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)

[wiki|Domains]

• [wiki|tRNA-binding domain] (aa 570-662) (accordinig to UniProt)

Structure

• [PDB|1WE0] (from ''Thermus thermophilus hb8 mutant'', 40% identity, 57% similarity) [Pubmed|10673435]
• [AF|P37465]

Modification

• phosphorylated on Ser-652 [Pubmed|20509597]

[wiki|Localization]

• cytoplasm (according to Swiss-Prot)

References

• 14651647,20509597,27120414,11732605