Difference between revisions of "MecA"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[genetic competence]]}},
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{{SubtiWiki category|[[proteolysis]]}}
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= This gene is a member of the following [[regulons]] =
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=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[genetic competence]]}},
 
{{SubtiWiki category|[[proteolysis]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 18:29, 8 December 2010

  • Description: negative regulator of competence, targets ComK to ClpC-ClpP degradation machine (in log Phase)

Gene name mecA
Synonyms
Essential no
Product adaptor protein
Function control of ComK degradation, regulation of competence
MW, pI 25 kDa, 4.209
Gene length, protein length 654 bp, 218 aa
Immediate neighbours yjbE, coiA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MecA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

genetic competence, proteolysis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU11520

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: mecA family (according to Swiss-Prot)
  • Paralogous protein(s): YpbH

Extended information on the protein

  • Kinetic information:
  • Domains:
    • N-terminal domain (1 ... 120): recruitment of protein substrates PubMed
    • C-terminal domain (121 ... 218): facilitates assembly of the ClpC-ClpP oligomer and acts as a degradation tag PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications