Mdr

• Description: multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)
  
  

Gene name	mdr
Synonyms	ycgD, bmr3
Essential	no
Product	multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)
Function	drug resistance
Gene expression levels in SubtiExpress: mdr
MW, pI	46 kDa, 9.701
Gene length, protein length	1278 bp, 426 aa
Immediate neighbours	lctP, ycgE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, resistance against toxins/ antibiotics

The gene

Basic information

• Locus tag: BSU03070

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P96712

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: mdr PubMed

• Sigma factor:

• Regulation: expression activated by glucose (3.6 fold) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)