Difference between revisions of "Mdr"

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|style="background:#ABCDEF;" align="center"|'''Function''' || drug resistance
 
|style="background:#ABCDEF;" align="center"|'''Function''' || drug resistance
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03070 mdr]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03070 mdr]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 9.701   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 9.701   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lctP]]'', ''[[ycgE]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lctP]]'', ''[[ycgE]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12101&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03070 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03070 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03070 Advanced_DNA]
 
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Revision as of 12:06, 13 May 2013

  • Description: multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)

Gene name mdr
Synonyms ycgD, bmr3
Essential no
Product multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)
Function drug resistance
Gene expression levels in SubtiExpress: mdr
MW, pI 46 kDa, 9.701
Gene length, protein length 1278 bp, 426 aa
Immediate neighbours lctP, ycgE
Sequences Protein DNA Advanced_DNA
Genetic context
Mdr context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Mdr expression.png
























Categories containing this gene/protein

transporters/ other, resistance against toxins/ antibiotics

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU03070

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation: expression activated by glucose (3.6 fold) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)