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  • Description: methionine aminopeptidase

Gene name map
Synonyms mapA
Essential yes PubMed
Product methionine aminopeptidase
Function removal of N-terminal methionine from nascent proteins
Gene expression levels in SubtiExpress: map
Interactions involving this protein in SubtInteract: Map
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation), Protein secretion
MW, pI 27 kDa, 6.393
Gene length, protein length 744 bp, 248 aa
Immediate neighbours adk, ybzG
Sequences Protein DNA DNA_with_flanks
Genetic context
Map context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Map expression.png















Categories containing this gene/protein

translation, protein modification, essential genes

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU01380

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides (according to Swiss-Prot)
  • Protein family: peptidase M24A family (according to Swiss-Prot)
  • Paralogous protein(s): YflG

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2MAT (from Escherichia coli, 46% identity, 65% similarity) PubMed
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information: strongly expressed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Arzu Sandikci, Felix Gloge, Michael Martinez, Matthias P Mayer, Rebecca Wade, Bernd Bukau, Günter Kramer
Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding.
Nat Struct Mol Biol: 2013, 20(7);843-50
[PubMed:23770820] [WorldCat.org] [DOI] (I p)

CongHui You, HongYan Lu, Agnieszka Sekowska, Gang Fang, YiPing Wang, Anne-Marie Gilles, Antoine Danchin
The two authentic methionine aminopeptidase genes are differentially expressed in Bacillus subtilis.
BMC Microbiol: 2005, 5;57
[PubMed:16207374] [WorldCat.org] [DOI] (I e)

J W Suh, S A Boylan, S H Oh, C W Price
Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region.
Gene: 1996, 169(1);17-23
[PubMed:8635744] [WorldCat.org] [DOI] (P p)