Difference between revisions of "ManR"

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'''Additional references:''' {{PubMed|20139185,22900538}}
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<pubmed>10627040, 20139185,9663674 </pubmed>
 
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 20:20, 8 April 2013

  • Description: transcriptional activator of the manP-manA-yjdF operon

Gene name manR
Synonyms yjdC
Essential no
Product transcriptional activator, PRD-type
Function regulation of mannose utilization
Gene expression levels in SubtiExpress: manR
Interactions involving this protein in SubtInteract: ManR
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 75 kDa, 8.04
Gene length, protein length 1944 bp, 648 aa
Immediate neighbours yjdB, manP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ManR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ManR expression.png



















Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, ManR regulon

The ManR regulon:

The gene

Basic information

  • Locus tag: BSU12000

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation by ManP inactivates ManR (in the absence of mannose), phosphorylation by HPr stimluates ManR PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
    • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
    • CcpA: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References