Difference between revisions of "ManR"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[CcpA regulon]]}}, | ||
{{SubtiWiki regulon|[[ManR regulon]]}} | {{SubtiWiki regulon|[[ManR regulon]]}} | ||
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=The [[ManR regulon]]:= | =The [[ManR regulon]]:= | ||
* ''[[manP]]-[[manA]]-[[yjdF]]'', ''[[manR]]'' | * ''[[manP]]-[[manA]]-[[yjdF]]'', ''[[manR]]'' | ||
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* '''Regulation:''' | * '''Regulation:''' | ||
** induced by mannose ([[ManR]]) {{PubMed|20139185}} | ** induced by mannose ([[ManR]]) {{PubMed|20139185}} | ||
| − | ** repressed by glucose ([[ManR]]) {{PubMed|20139185}} | + | ** repressed by glucose ([[CcpA]], [[ManR]]) {{PubMed|22900538,20139185}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[ManR]]: transcription activation in the presence of mannose and absence of glucose {{PubMed|20139185}} | ** [[ManR]]: transcription activation in the presence of mannose and absence of glucose {{PubMed|20139185}} | ||
| + | ** [[CcpA]]: transcription repression {{PubMed|22900538}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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=References= | =References= | ||
| − | <pubmed>10627040 20139185, 9663674 </pubmed> | + | <pubmed>10627040 20139185, 9663674 22900538 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:14, 23 August 2012
| Gene name | manR |
| Synonyms | yjdC |
| Essential | no |
| Product | transcriptional activator, PRD-type |
| Function | regulation of mannose utilization |
| Gene expression levels in SubtiExpress: manR | |
| Interactions involving this protein in SubtInteract: ManR | |
| Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
| MW, pI | 75 kDa, 8.04 |
| Gene length, protein length | 1944 bp, 648 aa |
| Immediate neighbours | yjdB, manP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
utilization of specific carbon sources, transcription factors and their control, phosphoproteins
This gene is a member of the following regulons
The ManR regulon:
The gene
Basic information
- Locus tag: BSU12000
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation by ManP inactivates ManR (in the absence of mannose), phosphorylation by HPr stimluates ManR PubMed
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31644
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
