malA

malA
168

6-phospho-alpha-glucosidase

locus
BSU_08180
Molecular weight
50.35 kDa
pI
4.74
Protein length
Gene length
function
maltose utilization
product
6-phospho-alpha-glucosidase
essential
no
ec
3.2.1.122
synonyms
malA, glvG, glvA, mdxK

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1486 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
890,022 → 891,371
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The protein
Catalyzed reaction/ biological activity
α-maltose 6'-phosphate + H2O --> D-glucose + D-glucose 6-phosphate (according to UniProt)
Protein family
[wiki|Glycosyl hydrolase 4 family] (according to UniProt)
Structure
[PDB|1U8X]
[AF|P54716]
[wiki|Localization]
membrane associated [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]-[gene|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]-[gene|E6C7733A12AF9A5322EED444E4A4FF1605A8B20F|malP]
description
[Pubmed|11489864]
regulation
induction by maltose ([protein|search|GlvR]) [Pubmed|11489864]
regulatory mechanism
[protein|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]: activation, [Pubmed|11489864], in [regulon|protein:AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|11489864], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|11489864], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]→[gene|E6C7733A12AF9A5322EED444E4A4FF1605A8B20F|malP]

2024-03-08 18:39:11

ghost

48

6a26149dfa8d59e889feb231a4a368771031054a

FD8255D46CE7F0F8F2F29E2D8219342876F518B7

Biological materials
Mutant
MGNA-C289 (glvA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2287 NBRP B. subtilis, Japan]
BKE08180 (Δ[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGACGACCTCCTTGAT,  downstream forward: _UP4_TAAATGAAATTCCCCCATTT
BKK08180 (Δ[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGACGACCTCCTTGAT,  downstream forward: _UP4_TAAATGAAATTCCCCCATTT
References
22900538,16707683,10627040,18763711,9765262,11489864,17676871,15341727,20618987

C650160C9E5B5F8587CA9E80A57BCCE97D701037

Page visits: 4063

Time of last update: 2024-03-28 10:25:12

Author of last update: Robert.warneke