Difference between revisions of "Maf"
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| − | * '''Description:''' cell division inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of [[ComGA]]<br/><br/> | + | * '''Description:''' [[cell division]] inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of [[ComGA]]<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || cell division inhibitor | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[cell division]] inhibitor |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || cell division control | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[cell division]] control |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28050 maf] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28050 maf] | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
| − | |||
| − | |||
| − | |||
| − | |||
<br/><br/> | <br/><br/> | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[cell division]]}} | + | {{SubtiWiki category|[[cell division]]}}, |
| + | {{SubtiWiki category|[[genetic competence]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| Line 80: | Line 77: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in ''in vitro'' experiments |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 95: | Line 92: | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| + | ** cytosolic protein {{PubMed|24164455}} | ||
** near the poles of competent cells {{PubMed|21564336}} | ** near the poles of competent cells {{PubMed|21564336}} | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=maf_2862572_2863141_-1 maf] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=maf_2862572_2863141_-1 maf] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 149: | Line 147: | ||
==Original publications== | ==Original publications== | ||
| − | + | <pubmed> 21564336 10841541 8387996 11948146 24164455 21926231</pubmed> | |
| − | <pubmed> 21564336 10841541 8387996 11948146 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:53, 16 March 2014
- Description: cell division inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of ComGA
| Gene name | maf |
| Synonyms | |
| Essential | no |
| Product | cell division inhibitor |
| Function | cell division control |
| Gene expression levels in SubtiExpress: maf | |
| Interactions involving this protein in SubtInteract: Maf | |
| MW, pI | 21 kDa, 5.711 |
| Gene length, protein length | 567 bp, 189 aa |
| Immediate neighbours | radC, spoIIB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell division, genetic competence
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28050
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: maf family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Cofactors: binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in in vitro experiments
- Effectors of protein activity:
Database entries
- Structure: 1EX2
- UniProt: Q02169
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
Jessica M Mann, Valerie J Carabetta, Ileana M Cristea, David Dubnau
Complex formation and processing of the minor transformation pilins of Bacillus subtilis.
Mol Microbiol: 2013, 90(6);1201-15
[PubMed:24164455]
[WorldCat.org]
[DOI]
(I p)
Veronica Guariglia-Oropeza, John D Helmann
Bacillus subtilis σ(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids.
J Bacteriol: 2011, 193(22);6223-32
[PubMed:21926231]
[WorldCat.org]
[DOI]
(I p)
Kenneth Briley, Peter Prepiak, Miguel J Dias, Jeanette Hahn, David Dubnau
Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis.
Mol Microbiol: 2011, 81(1);23-39
[PubMed:21564336]
[WorldCat.org]
[DOI]
(I p)
Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146]
[WorldCat.org]
[DOI]
(P p)
G Minasov, M Teplova, G C Stewart, E V Koonin, W F Anderson, M Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc Natl Acad Sci U S A: 2000, 97(12);6328-33
[PubMed:10841541]
[WorldCat.org]
[DOI]
(P p)
Y X Butler, Y Abhayawardhane, G C Stewart
Amplification of the Bacillus subtilis maf gene results in arrested septum formation.
J Bacteriol: 1993, 175(10);3139-45
[PubMed:8387996]
[WorldCat.org]
[DOI]
(P p)
