Difference between revisions of "Maf"

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(Reviews)
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* '''Description:''' septum formation <br/><br/>
+
* '''Description:''' cell division inhibitor in competent cells<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
Line 10: Line 10:
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || cell division inhibitor
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || septum formation
+
|style="background:#ABCDEF;" align="center"|'''Function''' || cell division control
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 5.711   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 5.711   

Revision as of 08:50, 22 May 2011

  • Description: cell division inhibitor in competent cells

Gene name maf
Synonyms
Essential no
Product cell division inhibitor
Function cell division control
MW, pI 21 kDa, 5.711
Gene length, protein length 567 bp, 189 aa
Immediate neighbours radC, spoIIB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Maf context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell division

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU28050

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: maf family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in in vitro experiments
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

PubMed

Original publications

Kenneth Briley, Peter Prepiak, Miguel J Dias, Jeanette Hahn, David Dubnau
Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis.
Mol Microbiol: 2011, 81(1);23-39
[PubMed:21564336] [WorldCat.org] [DOI] (I p)

G Minasov, M Teplova, G C Stewart, E V Koonin, W F Anderson, M Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc Natl Acad Sci U S A: 2000, 97(12);6328-33
[PubMed:10841541] [WorldCat.org] [DOI] (P p)

Y X Butler, Y Abhayawardhane, G C Stewart
Amplification of the Bacillus subtilis maf gene results in arrested septum formation.
J Bacteriol: 1993, 175(10);3139-45
[PubMed:8387996] [WorldCat.org] [DOI] (P p)