LutR

• Description: repressor of the lutA-lutB-lutC operon
  
  

Gene name	lutR
Synonyms	yvfI
Essential	no
Product	transcriptional repressor
Function	control of lactate utilization
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	19 kDa, 4.845
Gene length, protein length	525 bp, 175 aa
Immediate neighbours	lacR, lutP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU34180

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcriptional repressor of the lutA-lutB-lutC operon PubMed

• Protein family: GntR family of transcription factors

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: lactate acts as molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07007

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

References

Yunrong Chai, Roberto Kolter, Richard Losick
A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation.
J Bacteriol: 2009, 191(8);2423-30
[PubMed:19201793] [WorldCat.org] [DOI] (I p)