Difference between revisions of "LutP"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** expressed at high cell density ([[ComA]]) {{PubMed|16091051}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[ComA]]: transcription activation ([[ComA]]) {{PubMed|16091051}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed> 19201793, 18763711 </pubmed>
+
<pubmed> 19201793, 18763711 16091051</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 20:18, 15 February 2010

  • Description: lactate permease

Gene name lutP
Synonyms yvfH
Essential no
Product lactate permease
Function lactate uptake
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 59 kDa, 9.476
Gene length, protein length 1689 bp, 563 aa
Immediate neighbours lutR, sigL
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvfH context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU34190

Phenotypes of a mutant

poor growth with lactate as single carbon source PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: lactate uptake PubMed
  • Protein family: lactate permease family (according to Swiss-Prot)
  • Paralogous protein(s): LctP

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot), membrane associated PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

Your additional remarks

References

Yunrong Chai, Roberto Kolter, Richard Losick
A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation.
J Bacteriol: 2009, 191(8);2423-30
[PubMed:19201793] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Natalia Comella, Alan D Grossman
Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis.
Mol Microbiol: 2005, 57(4);1159-74
[PubMed:16091051] [WorldCat.org] [DOI] (P p)