Difference between revisions of "LutB"

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(Extended information on the protein)
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** induction by lactate [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
 
** induction by lactate [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
 
** less expressed under conditions of extreme iron limitation ([[FsrA]]) [http://www.ncbi.nlm.nih.gov/pubmed/18697947 PubMed]
 
** less expressed under conditions of extreme iron limitation ([[FsrA]]) [http://www.ncbi.nlm.nih.gov/pubmed/18697947 PubMed]
 +
** part of the iron sparing response ([[FsrA]]) {{PubMed|22389480}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[SinR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
 
** [[SinR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
 
** dual repression by [[LutR]] (inducer lactate) and [[SinR]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
 
** dual repression by [[LutR]] (inducer lactate) and [[SinR]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19201793 PubMed]
** [[FsrA]]: translational repression [http://www.ncbi.nlm.nih.gov/pubmed/18697947 PubMed]
+
** [[FsrA]]: translational repression {{PubMed|18697947}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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=References=
 
=References=
  
<pubmed>18697947,16430695,,19201793, 19201793 </pubmed>
+
<pubmed>18697947,16430695,22389480,19201793, 19201793 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:07, 14 March 2012

  • Description: lactate catabolic enzyme

Gene name lutB
Synonyms yvfW
Essential no
Product lactate oxidase
Function lactate utilization
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 53 kDa, 5.848
Gene length, protein length 1437 bp, 479 aa
Immediate neighbours lutC, lutA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvfW context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

FsrA regulon, LutR regulon, SinR regulon

The gene

Basic information

  • Locus tag: BSU34040

Phenotypes of a mutant

no growth with lactate as the single carbon source PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: oxidation of lactate to pyruvate PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): contains an iron-sulfur cluster
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

Your additional remarks

References