LtaS

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  • Description: polyglycerolphosphate lipoteichoic acid synthase

Gene name ltaS
Synonyms yflE
Essential no
Product major lipoteichoic acid synthase
Function biosynthesis of lipoteichoic acid
Gene expression levels in SubtiExpress: ltaS
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 74 kDa, 5.202
Gene length, protein length 1947 bp, 649 aa
Immediate neighbours nagP, yflD
Sequences Protein DNA DNA_with_flanks
Genetic context
YflE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LtaS expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: LTA synthase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on Thr-297 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: ltaS (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews: PubMed

Nathalie T Reichmann, Angelika Gründling
Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes.
FEMS Microbiol Lett: 2011, 319(2);97-105
[PubMed:21388439] [WorldCat.org] [DOI] (I p)

Original publications

Michihiro Hashimoto, Takahiro Seki, Satoshi Matsuoka, Hiroshi Hara, Kei Asai, Yoshito Sadaie, Kouji Matsumoto
Induction of extracytoplasmic function sigma factors in Bacillus subtilis cells with defects in lipoteichoic acid synthesis.
Microbiology (Reading): 2013, 159(Pt 1);23-35
[PubMed:23103977] [WorldCat.org] [DOI] (I p)

Mirka E Wörmann, Rebecca M Corrigan, Peter J Simpson, Steve J Matthews, Angelika Gründling
Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes.
Mol Microbiol: 2011, 79(3);566-83
[PubMed:21255105] [WorldCat.org] [DOI] (I p)

Kathrin Schirner, Jon Marles-Wright, Richard J Lewis, Jeff Errington
Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis.
EMBO J: 2009, 28(7);830-42
[PubMed:19229300] [WorldCat.org] [DOI] (I p)

Duo Lu, Mirka E Wörmann, Xiaodong Zhang, Olaf Schneewind, Angelika Gründling, Paul S Freemont
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.
Proc Natl Acad Sci U S A: 2009, 106(5);1584-9
[PubMed:19168632] [WorldCat.org] [DOI] (I p)

Angelika Gründling, Olaf Schneewind
Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus.
Proc Natl Acad Sci U S A: 2007, 104(20);8478-83
[PubMed:17483484] [WorldCat.org] [DOI] (P p)

Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965] [WorldCat.org] [DOI] (P p)