LtaS

Gene name	ltaS
Synonyms	yflE
Essential	no
Product	major lipoteichoic acid synthase
Function	biosynthesis of lipoteichoic acid
Gene expression levels in SubtiExpress: ltaS
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	74 kDa, 5.202
Gene length, protein length	1947 bp, 649 aa
Immediate neighbours	nagP, yflD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins, phosphoproteins

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LTA synthase family (according to Swiss-Prot)

• Paralogous protein(s): YfnI, YqgS, YvgJ

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Thr-297 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane, at the septum of the cell PubMed
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 2W8D

• UniProt: O34952

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ltaS (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews: PubMed

Nathalie T Reichmann, Angelika Gründling
Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes.
FEMS Microbiol Lett: 2011, 319(2);97-105
[PubMed:21388439] [WorldCat.org] [DOI] (I p)