LrpC

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  • Description: sequence-independent DNA-binding and DNA-bending protein (Lrp family), facilitates the formation of higher order protein-DNA complexes

Gene name lrpC
Synonyms ydaI
Essential no
Product DNA-binding and -bending protein
Function DNA repair/ recombination
Gene expression levels in SubtiExpress: lrpC
MW, pI 16 kDa, 7.743
Gene length, protein length 432 bp, 144 aa
Immediate neighbours ydzA, topB
Sequences Protein DNA DNA_with_flanks
Genetic context
LrpC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LrpC expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04250

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information: 50 ... 300 molecules per cell PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Paul Thaw, Svetlana E Sedelnikova, Tatyana Muranova, Sebastian Wiese, Sylvia Ayora, Juan C Alonso, Arie B Brinkman, Jasper Akerboom, John van der Oost, John B Rafferty
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.
Nucleic Acids Res: 2006, 34(5);1439-49
[PubMed:16528101] [WorldCat.org] [DOI] (I e)

Gema López-Torrejón, María I Martínez-Jiménez, Silvia Ayora
Role of LrpC from Bacillus subtilis in DNA transactions during DNA repair and recombination.
Nucleic Acids Res: 2006, 34(1);120-9
[PubMed:16407330] [WorldCat.org] [DOI] (I e)

Christophe Beloin, Josette Jeusset, Bernard Revet, Gilles Mirambeau, Francoise Le Hégarat, Eric Le Cam
Contribution of DNA conformation and topology in right-handed DNA wrapping by the Bacillus subtilis LrpC protein.
J Biol Chem: 2003, 278(7);5333-42
[PubMed:12458218] [WorldCat.org] [DOI] (P p)

C Beloin, R Exley, A L Mahé, M Zouine, S Cubasch, F Le Hégarat
Characterization of LrpC DNA-binding properties and regulation of Bacillus subtilis lrpC gene expression.
J Bacteriol: 2000, 182(16);4414-24
[PubMed:10913073] [WorldCat.org] [DOI] (P p)

A Tapias, G López, S Ayora
Bacillus subtilis LrpC is a sequence-independent DNA-binding and DNA-bending protein which bridges DNA.
Nucleic Acids Res: 2000, 28(2);552-9
[PubMed:10606655] [WorldCat.org] [DOI] (I p)

C Beloin, S Ayora, R Exley, L Hirschbein, N Ogasawara, Y Kasahara, J C Alonso, F L Hégarat
Characterization of an lrp-like (lrpC) gene from Bacillus subtilis.
Mol Gen Genet: 1997, 256(1);63-71
[PubMed:9341680] [WorldCat.org] [DOI] (P p)