lmrB

168

lincomycin-resistance protein (multidrug resistance pump)

locus: BSU_02670

Molecular weight: 51.54 kDa

pI: 9.7

Protein length: 479 aa

Gene length: 1440 bp

function: resistance to lincomycin

product: lincomycin-resistance protein

essential: no

synonyms: lmrB, yccA

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

Gene

Coordinates: 288,653  290,092

Advertisement

The protein

Protein family

• [wiki|major facilitator superfamily] (according to UniProt)
• [wiki|EmrB family] (according to UniProt)

Structure

• [AF|O35018]

Paralogous protein(s)

• [protein|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA], [protein|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB]

[wiki|Localization]

• cell membrane (according to UniProt)

Biological materials

Mutant

• GP1701 (''[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]''::''aphA3''), available in [wiki|Jörg Stülke]'s lab
• GP1703 (''[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]''::''aphA3'' ''[gene|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB]''::''spc''), available in [wiki|Jörg Stülke]'s lab
• BKE02670 ([gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC,  downstream forward: _UP4_TAATATGAAAAGCCCCTGAC
• BKK02670 ([gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC,  downstream forward: _UP4_TAATATGAAAAGCCCCTGAC

References

• 15317768,17483215,12499232,21815947