Lgt

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  • Description: prolipoprotein diacylglyceryl transferase

Gene name lgt
Synonyms gerF, yvoC
Essential no
Product prolipoprotein diacylglyceryl transferase
Function lipomodification of lipoproteins
Interactions involving this protein in SubtInteract: Lgt
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism, Protein secretion
MW, pI 30 kDa, 8.96
Gene length, protein length 807 bp, 269 aa
Immediate neighbours yvoD, hprK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Lgt context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

protein modification, germination, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34990

Phenotypes of a mutant

  • reduced ability of spores to germinate with alanine due ti reduced activity of the GerAA-GerAB-GerAC germinant receptor PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: lgt family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: membrane associated PubMed

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

PubMed


Original publications

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Takao Igarashi, Barbara Setlow, Madan Paidhungat, Peter Setlow
Effects of a gerF (lgt) mutation on the germination of spores of Bacillus subtilis.
J Bacteriol: 2004, 186(10);2984-91
[PubMed:15126458] [WorldCat.org] [DOI] (P p)

S Leskelä, E Wahlström, V P Kontinen, M Sarvas
Lipid modification of prelipoproteins is dispensable for growth but essential for efficient protein secretion in Bacillus subtilis: characterization of the Lgt gene.
Mol Microbiol: 1999, 31(4);1075-85
[PubMed:10096076] [WorldCat.org] [DOI] (P p)

J Bengtsson, H Tjalsma, C Rivolta, L Hederstedt
Subunit II of Bacillus subtilis cytochrome c oxidase is a lipoprotein.
J Bacteriol: 1999, 181(2);685-8
[PubMed:9882689] [WorldCat.org] [DOI] (P p)

A Galinier, M Kravanja, R Engelmann, W Hengstenberg, M C Kilhoffer, J Deutscher, J Haiech
New protein kinase and protein phosphatase families mediate signal transduction in bacterial catabolite repression.
Proc Natl Acad Sci U S A: 1998, 95(4);1823-8
[PubMed:9465101] [WorldCat.org] [DOI] (P p)