LctP

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  • Description: lactate permease, excretion

Gene name lctP
Synonyms ycgC
Essential no
Product L-lactate permease
Function lactate excretion
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 57 kDa, 9.766
Gene length, protein length 1623 bp, 541 aa
Immediate neighbours ldh, mdr
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
LctP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LctP expression.png




























Categories containing this gene/protein

transporters/ other, carbon core metabolism, membrane proteins

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

  • Locus tag: BSU03060

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: lactate permease family (according to Swiss-Prot)
  • Paralogous protein(s): LutP

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions (Rex) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, T Hoffmann, M Marino, H Nedjari, E Presecan-Siedel, O Dreesen, P Glaser, D Jahn
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression.
J Bacteriol: 2000, 182(11);3072-80
[PubMed:10809684] [WorldCat.org] [DOI] (P p)