Difference between revisions of "LctP"

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|style="background:#ABCDEF;" align="center"|'''Function''' || lactate excretion  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || lactate excretion  
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03060 lctP]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03060 lctP]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ldh]]'', ''[[mdr]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ldh]]'', ''[[mdr]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12100&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03060 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03060 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03060 Advanced_DNA]
 
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Revision as of 12:06, 13 May 2013

  • Description: lactate permease, excretion

Gene name lctP
Synonyms ycgC
Essential no
Product L-lactate permease
Function lactate excretion
Gene expression levels in SubtiExpress: lctP
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 57 kDa, 9.766
Gene length, protein length 1623 bp, 541 aa
Immediate neighbours ldh, mdr
Sequences Protein DNA Advanced_DNA
Genetic context
LctP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LctP expression.png




























Categories containing this gene/protein

transporters/ other, carbon core metabolism, membrane proteins

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

  • Locus tag: BSU03060

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: lactate permease family (according to Swiss-Prot)
  • Paralogous protein(s): LutP

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions (Rex) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, T Hoffmann, M Marino, H Nedjari, E Presecan-Siedel, O Dreesen, P Glaser, D Jahn
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression.
J Bacteriol: 2000, 182(11);3072-80
[PubMed:10809684] [WorldCat.org] [DOI] (P p)