KtrC

From SubtiWiki
Revision as of 16:06, 17 April 2015 by Jstuelk (talk | contribs) (References)
Jump to: navigation, search
  • Description: low affinity potassium transporter KtrC-KtrD, peripheric membrane component

Gene name ktrC
Synonyms ylxV, yzaC, ykqB
Essential no
Product low affinity potassium transporter KtrC-KtrD,
peripheric membrane component (proton symport)
Function potassium uptake
Gene expression levels in SubtiExpress: ktrC
Interactions involving this protein in SubtInteract: KtrC
Metabolic function and regulation of this protein in SubtiPathways:
Metal ion homeostasis, ktrC
MW, pI 24 kDa, 5.63
Gene length, protein length 663 bp, 221 aa
Immediate neighbours ykqA, adeC
Sequences Protein DNA DNA_with_flanks
Genetic context
YkqB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
KtrC expression.png















Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU14510

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): KtrA

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:
    • the protein binds c-di-AMP PubMed

Database entries

  • Structure:
  • KEGG entry: [4]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: constitutively expressed PubMed
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 576 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 453 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 601 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Erhard Bremer, University of Marburg, Germany homepage

Your additional remarks

References

Reviews

Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574] [WorldCat.org] [DOI] (I p)

Original publications

Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116] [WorldCat.org] [DOI] (I p)

Gudrun Holtmann, Evert P Bakker, Nobuyuki Uozumi, Erhard Bremer
KtrAB and KtrCD: two K+ uptake systems in Bacillus subtilis and their role in adaptation to hypertonicity.
J Bacteriol: 2003, 185(4);1289-98
[PubMed:12562800] [WorldCat.org] [DOI] (P p)