Difference between revisions of "KinD"

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(References)
(Extended information on the protein)
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** activity is stimulated by direct or indirect interaction with [[Med]] {{PubMed|21622736}}
 
** activity is stimulated by direct or indirect interaction with [[Med]] {{PubMed|21622736}}
  
* '''Interactions:''' [[KinD]]-[[Spo0F]]
+
* '''[[SubtInteract|Interactions]]:'''
 +
** [[KinD]]-[[Spo0F]]
  
* '''Localization:''' membrane
+
* '''[[Localization]]:''' membrane
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 20:58, 21 November 2011

Gene name kinD
Synonyms ykvD
Essential no
Product two-component sensor kinase
Function initiation of sporulation
Interactions involving this protein in SubtInteract: KinD
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 56 kDa, 6.745
Gene length, protein length 1518 bp, 506 aa
Immediate neighbours eag, mhqR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
KinD context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

protein modification, transcription factors and their control, phosphorelay, membrane proteins, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU13660

Phenotypes of a mutant

deletion of kinD suppresses the sporulation defect of matrix mutants, while its overproduction delays sporulation PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • autophosphorylation, phosphorylation of Spo0F, regulates the onset of sporulation by inhibiting the activity of Spo0A until matrix, or a component therein, is sensed PubMed
    • dual role as a phosphatase or a kinase, activity is linked to the presence of extracellular matrix in the biofilms PubMed
    • mainly active in the younger, outer regions of a colony (with KinC) PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:
    • activity is stimulated by direct or indirect interaction with Med PubMed

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additonal publications: PubMed