KinA

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Gene name kinA
Synonyms spoIIF, spoIIJ, gsiC, scoB, scoD
Essential no
Product two-component sensor kinase
Function initiation of sporulation
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 68 kDa, 5.491
Gene length, protein length 1818 bp, 606 aa
Immediate neighbours pbpH, patA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
KinA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU13990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • autophosphorylation, phosphorylation of Spo0F
    • mainly active in the older, inner regions of a colony (with KinB) PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity: interaction with KipI or Sda inhibits autophosphorylation of KinA PubMed
  • Localization:

Database entries

  • Structure: 2VLG (PAS domain)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References