Difference between revisions of "KinA"

From SubtiWiki
Jump to: navigation, search
Line 49: Line 49:
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
 
{{SubtiWiki regulon|[[SigH regulon]]}},
 
{{SubtiWiki regulon|[[SigH regulon]]}},
{{SubtiWiki regulon|[[Spo0A regulon]]}}
+
{{SubtiWiki regulon|[[Spo0A regulon]]}},
 +
{{SubtiWiki regulon|[[stringent response]]}}
  
 
=The gene=
 
=The gene=
Line 92: Line 93:
 
* '''Cofactor(s):'''
 
* '''Cofactor(s):'''
  
* '''Effectors of protein activity:''' interaction with [[KipI]] or [[Sda]] inhibits autophosphorylation of [[KinA]] {{PubMed|9334321,15023339}}
+
* '''Effectors of protein activity:'''  
 +
** interaction with [[KipI]] or [[Sda]] inhibits autophosphorylation of [[KinA]] {{PubMed|9334321,15023339}}
 +
** autophosphorylation is inhibited by [[SivA]] and [[BslA]] {{PubMed|23335417}}
  
 
* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
Line 120: Line 123:
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 kinA] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 kinA] {{PubMed|22383849}}
  
* '''Sigma factor:''' [[SigH]] {{PubMed|1569009}}
+
* '''[[Sigma factor]]:''' [[SigH]] {{PubMed|1569009}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 
** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|9644251}}
 
** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|9644251}}
 +
** induced upon addition of decoyinine (positive [[stringent response]]) {{PubMed|23378509}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
Line 153: Line 157:
 
==Original Publications==
 
==Original Publications==
 
'''Additional original publications:''' {{PubMed|23169620}}
 
'''Additional original publications:''' {{PubMed|23169620}}
<pubmed>20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 </pubmed>
+
<pubmed>20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:30, 5 February 2013

Gene name kinA
Synonyms spoIIF, spoIIJ, gsiC, scoB, scoD
Essential no
Product two-component sensor kinase
Function initiation of sporulation
Gene expression levels in SubtiExpress: kinA
Interactions involving this protein in SubtInteract: KinA
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 68 kDa, 5.491
Gene length, protein length 1818 bp, 606 aa
Immediate neighbours pbpH, patA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
KinA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
KinA expression.png















Categories containing this gene/protein

protein modification, transcription factors and their control, phosphorelay, phosphoproteins

This gene is a member of the following regulons

SigH regulon, Spo0A regulon, stringent response

The gene

Basic information

  • Locus tag: BSU13990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • autophosphorylation, phosphorylation of Spo0F
    • mainly active in the older, inner regions of a colony (with KinB) PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2VLG (PAS domain)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Liza Gross
Built-in timer delays differentiation.
PLoS Biol: 2012, 10(1);e1001254
[PubMed:22303284] [WorldCat.org] [DOI] (I p)

Original Publications

Additional original publications: PubMed