KhtT

• Description: K+/H+ antiporter for K+ efflux
  
  

Gene name	yhaT
Synonyms
Essential	no
Product	K+/H+ antiporter for K+ efflux
Function	potassium ion efflux
Gene expression levels in SubtiExpress: khtT
Interactions involving this protein in SubtInteract: KhtT
MW, pI	18 kDa, 4.892
Gene length, protein length	495 bp, 165 aa
Immediate neighbours	khtU, khtS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins

The gene

Basic information

• Locus tag: BSU09860

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • contains a RCK_C domain at the C-terminus (according to UniProt, [2])

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • KhtT-KhtU PubMed

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07535

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: khtS-khtT-khtU PubMed

• Expression browser: khtT PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Pete Chandrangsu, Renata Dusi, Chris J Hamilton, John D Helmann
Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways.
Mol Microbiol: 2014, 91(4);706-15
[PubMed:24330391] [WorldCat.org] [DOI] (I p)

Makoto Fujisawa, Masahiro Ito, Terry A Krulwich
Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity.
Proc Natl Acad Sci U S A: 2007, 104(33);13289-94
[PubMed:17679694] [WorldCat.org] [DOI] (P p)

Makoto Fujisawa, Yuko Wada, Masahiro Ito
Modulation of the K+ efflux activity of Bacillus subtilis YhaU by YhaT and the C-terminal region of YhaS.
FEMS Microbiol Lett: 2004, 231(2);211-7
[PubMed:14987767] [WorldCat.org] [DOI] (P p)