Difference between revisions of "IseA"
| Line 94: | Line 94: | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' | + | * '''Regulation:''' |
| + | * repressed by [[WalR]] {{PubMed|17581128}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | * [[WalR]]: transcription repression {{PubMed|17581128}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 120: | Line 122: | ||
=References= | =References= | ||
| − | <pubmed>17581128,18761694,17483219,, </pubmed> | + | <pubmed>17581128,18761694,17483219, 20059685, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:40, 12 January 2010
- Description: inhibits in vitro activity of cell wall endopeptidases LytE and LytF, inhibits cell separation
| Gene name | iseA |
| Synonyms | yoeB |
| Essential | no |
| Product | inhibitor of autolysins |
| Function | protection against cell envelope stress |
| MW, pI | 19 kDa, 10.176 |
| Gene length, protein length | 543 bp, 181 aa |
| Immediate neighbours | yoeA, trnSL-Arg1 |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU18380
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O34841
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Hiroki Yamamoto, Masayuki Hashimoto, Yuhei Higashitsuji, Hiroyuki Harada, Nozomi Hariyama, Lisa Takahashi, Tomoaki Iwashita, Seika Ooiwa, Junichi Sekiguchi
Post-translational control of vegetative cell separation enzymes through a direct interaction with specific inhibitor IseA in Bacillus subtilis.
Mol Microbiol: 2008, 70(1);168-82
[PubMed:18761694]
[WorldCat.org]
[DOI]
(I p)
Paola Bisicchia, David Noone, Efthimia Lioliou, Alistair Howell, Sarah Quigley, Thomas Jensen, Hanne Jarmer, Kevin M Devine
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis.
Mol Microbiol: 2007, 65(1);180-200
[PubMed:17581128]
[WorldCat.org]
[DOI]
(P p)
Letal I Salzberg, John D Helmann
An antibiotic-inducible cell wall-associated protein that protects Bacillus subtilis from autolysis.
J Bacteriol: 2007, 189(13);4671-80
[PubMed:17483219]
[WorldCat.org]
[DOI]
(P p)
