IolW

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  • Description: scyllo-inositol dehydrogenase, general stress protein

Gene name yvaA
Synonyms
Essential no
Product scyllo-inositol dehydrogenase
Function unknown
Gene expression levels in SubtiExpress: iolW
MW, pI 39 kDa, 5.457
Gene length, protein length 1074 bp, 358 aa
Immediate neighbours csoR, azoR2
Sequences Protein DNA DNA_with_flanks
Genetic context
YvaA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
IolW expression.png
























Categories containing this gene/protein

utilization of specific carbon sources, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU33530

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: gfo/idh/mocA family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 313 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 1480 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Kosei Tanaka, Shintaro Tajima, Shinji Takenaka, Ken-ichi Yoshida
An improved Bacillus subtilis cell factory for producing scyllo-inositol, a promising therapeutic agent for Alzheimer's disease.
Microb Cell Fact: 2013, 12;124
[PubMed:24325193] [WorldCat.org] [DOI] (I e)

Tetsuro Morinaga, Hitoshi Ashida, Ken-Ichi Yoshida
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 5);1538-1546
[PubMed:20133360] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)