InfC

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  • Description: translation initiation factor IF-3

Gene name infC
Synonyms
Essential yes PubMed
Product initiation factor IF-3
Function translation
MW, pI 19 kDa, 10.342
Gene length, protein length 519 bp, 173 aa
Immediate neighbours rpmI, yscA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
InfC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28870

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

translation, essential genes

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: IF-3 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1TIF (N-terminal domain, Geobacillus stearothermophilus), 1TIG (C-terminal domain, Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
    • binding of RplT to a RNA site in the infC leader region causes transcription termination PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Nasslie Choonee, Sergine Even, Lena Zig, Harald Putzer
Ribosomal protein L20 controls expression of the Bacillus subtilis infC operon via a transcription attenuation mechanism.
Nucleic Acids Res: 2007, 35(5);1578-88
[PubMed:17289755] [WorldCat.org] [DOI] (I p)

Christine Eymann, Georg Homuth, Christian Scharf, Michael Hecker
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.
J Bacteriol: 2002, 184(9);2500-20
[PubMed:11948165] [WorldCat.org] [DOI] (P p)