Difference between revisions of "InfB"

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(Extended information on the protein)
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[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 14:02, 4 August 2010

  • Description: translation initiation factor IF-2

Gene name infB
Synonyms
Essential yes PubMed
Product initiation factor IF-2
Function translation
MW, pI 78 kDa, 5.191
Gene length, protein length 2148 bp, 716 aa
Immediate neighbours ylxQ, ylxP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
InfB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU16630

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: IF-2 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: Nucleotide-binding domain that competitively binds GTP or ppGpp PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: GTP or ppGpp PubMed
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 1D1N (fMet-tRNA-fMet binding domain, Geobacillus stearothermophilus), 1Z9B (C1-subdomain, Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information: Putative cellular metabolic sensor and regulator that oscillates between an active GTP-bound form under conditions allowing active protein syntheses and an inactive ppGpp-bound form when shortage of nutrients PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References