Difference between revisions of "Icd"

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(Expression and regulation)
(Expression and regulation)
Line 95: Line 95:
  
 
* '''Regulation:''' catabolite repression ([[CcpA]]), repression by glucose + glutamate ([[CcpC]])
 
* '''Regulation:''' catabolite repression ([[CcpA]]), repression by glucose + glutamate ([[CcpC]])
 
+
''[[icd]]'': constitutive
 
* '''Regulatory mechanism:''' [[CcpA]]: transcription repression, [[CcpC]]: transcription repression
 
* '''Regulatory mechanism:''' [[CcpA]]: transcription repression, [[CcpC]]: transcription repression
  

Revision as of 15:56, 9 February 2009

  • Description: write here

Gene name icd
Synonyms citC
Essential
Product isocitrate dehydrogenase (EC 1.1.1.42)
Function
MW, pI 46 kDa, 4.833
Gene length, protein length 1269 bp, 423 aa
Immediate neighbours
Gene sequence (+200bp) Protein sequence
Genetic context
Icd context.gif



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry:
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: catabolite repression (CcpA), repression by glucose + glutamate (CcpC)

icd: constitutive

  • Regulatory mechanism: CcpA: transcription repression, CcpC: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Matsuno K, Blais T, Serio AW, Conway T, Henkin TM, Sonenshein AL (1999) Metabolic imbalance and sporulation in an isocitrate dehydrogenase mutant of Bacillus subtilis. J Bacteriol 181:3382-3391. PubMed
  2. Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC (2002) Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/ phosphatase. J Biol Chem 277: 7567-7573. PubMed
  3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed