Difference between revisions of "HxlR"

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(Basic information/ Evolution)
(Basic information/ Evolution)
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:''' activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
+
* '''Catalyzed reaction/ biological activity:''' transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
  
 
* '''Protein family:''' [[MarR/DUF24 family]]
 
* '''Protein family:''' [[MarR/DUF24 family]]

Revision as of 14:01, 20 April 2012

Gene name hxlR
Synonyms yckH
Essential no
Product MarR/DUF24 family transcription activator
Function regulation of the ribulose monophosphate pathway
MW, pI 14 kDa, 6.358
Gene length, protein length 360 bp, 120 aa
Immediate neighbours hxlA, srfAA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HxlR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HxlR expression.png


























Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The HxlR regulon:

The gene

Basic information

  • Locus tag: BSU03470

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: formaldehyde stimulates transcription activation by HxlR

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: hxlR (according to DBTBS)
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)

Nobuo Kato, Hiroya Yurimoto, Rudolf K Thauer
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem: 2006, 70(1);10-21
[PubMed:16428816] [WorldCat.org] [DOI] (P p)

H Yasueda, Y Kawahara, S Sugimoto
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
J Bacteriol: 1999, 181(23);7154-60
[PubMed:10572115] [WorldCat.org] [DOI] (P p)