HutU

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  • Description: urocanase

Gene name hutU
Synonyms
Essential no
Product urocanase
Function histidine utilization
Gene expression levels in SubtiExpress: hutU
Metabolic function and regulation of this protein in SubtiPathways:
hutU
MW, pI 60 kDa, 5.664
Gene length, protein length 1656 bp, 552 aa
Immediate neighbours hutH, hutI
Sequences Protein DNA DNA_with_flanks
Genetic context
HutU context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HutU expression.png



















Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

CcpA regulon, CodY regulon, HutP regulon

The gene

Basic information

  • Locus tag: BSU39360

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

  • A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O (according to Swiss-Prot)
  • Protein family: urocanase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (CcpA) PubMed
    • induced by histidine (HutP) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original publications