hutP

168

transcriptional antiterminator of the [gene|search|hut ]operon

locus: BSU_39340

Molecular weight: 16.43 kDa

pI: 6.06

Protein length: 151 aa

Gene length: 456 bp

function: regulation of histidine utilization

product: transcriptional antiterminator

essential: no

synonyms: hutP, hutP1

List of homologs in different organisms

Gene

Coordinates: 4,041,483 → 4,041,938

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The protein

Protein family

• hutP family (single member, according to UniProt)

[wiki|Cofactors]

• Mg²⁺ [pubmed|29035529]
• L-His [pubmed|23748184]

Structure

• [PDB|3BOY] (complex bound  to the [gene|search|hut] mRNA),  [PDB|1WPT]
• [AF|P10943]

Effectors of protein activity

• HutP binds its RNA target to cause antitermination in the presence of histidine [Pubmed|23748184]

Biological materials

Mutant

• BKE39340 (Δ[gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGAATCACTCAATTCC,  downstream forward: _UP4_TGAAACAGCCCATAGATCTT
• BKK39340 (Δ[gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATGAATCACTCAATTCC,  downstream forward: _UP4_TGAAACAGCCCATAGATCTT

References

Reviews

• 17395359,16427271,22933560,31100987

Research papers

• 28510182,23748184,10712704,18445631,15758992,15242603,14763987,15273277,18445631,8071225,16192572,29035529