HutM

From SubtiWiki
Revision as of 14:58, 16 May 2013 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: histidine permease

Gene name hutM
Synonyms
Essential no
Product histidine permease
Function histidine uptake
Gene expression levels in SubtiExpress: hutM
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 51 kDa, 9.007
Gene length, protein length 1425 bp, 475 aa
Immediate neighbours hutG, pdp
Sequences Protein DNA DNA_with_flanks
Genetic context
HutM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HutM expression.png















Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, utilization of amino acids, membrane proteins

This gene is a member of the following regulons

CcpA regulon, CodY regulon, HutP regulon

The gene

Basic information

  • Locus tag: BSU39390

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: secondary amino acid transporter

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (CcpA) PubMed
    • induced by histidine (HutP) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Robert A Bender
Regulation of the histidine utilization (hut) system in bacteria.
Microbiol Mol Biol Rev: 2012, 76(3);565-84
[PubMed:22933560] [WorldCat.org] [DOI] (I p)


Original publications