Difference between revisions of "HutI"

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|style="background:#ABCDEF;" align="center"|'''Function''' || histidine utilization  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || histidine utilization  
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU39370 hutI]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''

Revision as of 17:32, 7 August 2012

  • Description: imidazolone-5-propionate hydrolase

Gene name hutI
Synonyms
Essential no
Product imidazolone-5-propionate hydrolase
Function histidine utilization
Gene expression levels in SubtiExpress: hutI
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 45 kDa, 5.215
Gene length, protein length 1263 bp, 421 aa
Immediate neighbours hutU, hutG
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HutI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HutI expression.png




























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

CcpA regulon, CodY regulon, HutP regulon

The gene

Basic information

  • Locus tag: BSU39370

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ (according to Swiss-Prot)
  • Protein family: hutI family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (CcpA) PubMed
    • induced by histidine (HutP) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References