htrC

168

similar to quality control membrane serine protease [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA]

locus: BSU_40360

Molecular weight: 42.63 kDa

pI: 5.32

Protein length: 400 aa

Gene length: 1203 bp

function: unknown

product: putative quality control membrane protease

essential: no

synonyms: htrC, yycK, yyxA

List of homologs in different organisms, belongs to COG0265 (Galperin et al., 2021)

Gene

Coordinates: 4,147,567  4,148,769

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The protein

Protein family

• Peptidase S1C family (with [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA] and [protein|796216BE9CD6DADFEADC29497253C81BF496A2ED|htrB], according to UniProt)

[wiki|Domains]

• transmembrane helix (aa 22 - 42) (according to UniProt)
• [wiki|PDZ domain] (aa 295 - 392) (according to UniProt)

Structure

• [PDB|3QO6] (from Arabidopsis thaliana, 37% identity) [pubmed|21532594]
• [AF|P39668]

Paralogous protein(s)

• [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA]

[wiki|Localization]

• inner spore membrane [Pubmed|26731423]

Biological materials

Mutant

• MGNA-B823 (yycK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1822 NBRP B. subtilis, Japan]
• BKE40360 ([gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40360 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTCCATCCTTTCCAAG,  downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT
• BKK40360 ([gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40360 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTCCATCCTTTCCAAG,  downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT

References

Reviews

• 21326199,34410368

Original Publications

• 17600057,12270824,11555295,18957862,10692364,21624103,22307758,22092710,24362423,9829949,21630458,24115457,25384476,26731423,21532594